Thermo Fisher Scientific Angiogenin Polyclonal Antibody
Thermo Fisher Scientific의 Angiogenin Polyclonal Antibody는 인간, 마우스, 랫트 반응성을 지닌 토끼 IgG 폴리클로날 항체입니다. Western blot과 IHC에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 혈관신생 관련 연구 및 ALS, PD 등 질환 연구에 적합합니다.
- 카탈로그번호
- PA534422
- 판매단위
- pk
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Thermo Fisher Scientific Angiogenin Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 3 publications |
| Immunohistochemistry (IHC) | 20 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid synthetic peptide near the center of human ANG |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551774 |
Product Specific Information
- A suggested positive control is rat liver tissue lysate.
- PA5-34422 can be used with blocking peptide PEP-1464.
Target Information
Angiogenin (ANG or ANG I) plays an essential role in neovascularization and new blood vessel formation. It is similar to pancreatic ribonuclease A and acts as a tRNA-specific ribonuclease, inhibiting protein synthesis by hydrolyzing cellular tRNAs. ANG interacts with endothelial cell-surface actin, influencing cytoskeletal organization. It is implicated in solid tumor development, and its antagonists can inhibit tumor growth. Mutations in ANG are associated with susceptibility to amyotrophic lateral sclerosis type 9 (ALS9), linking ANG genetically to ALS and Parkinson’s disease (PD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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