Thermo Fisher Scientific H2A.Zac pan-acetyl (K4,K7,K11,K13) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human H2AFZ(Accession P0C0S5), corresponding to amino acid residues M1-S21. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:H2A.Zac pan-acetyl (K4,K7,K11,K13),uniProtId:P0C0S5-1,ncbiNodeId:9606,antigenRange:1-21,antigenLength:128,antigenImageFileName:PA5-114690_H2A.Zac_pan-acetyl_K4,K7,K11,K13_P0C0S5-1_Rabbit.svg,antigenImageFileNamePDP:PA5-114690_H2A.Zac_pan-acetyl_K4,K7,K11,K13_P0C0S5-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2899326

Product Specific Information

Antibody detects endogenous levels of Acetyl-H2A.Z only when acetylated at Lys4/7/11/13.

Target Information

H2A.Zac pan-acetyl (K4,K7,K11,K13) is classified under histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.