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Thermo Fisher Scientific FOXO1/FOXO3/FOXO4 Polyclonal Antibody
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FOXO1/FOXO3/FOXO4 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot, IHC, ICC/IF에 사용 가능. 인간, 생쥐, 랫트 반응성. 고순도 친화 크로마토그래피 정제, -20°C 보관.
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마지막 업데이트 2025. 08. 05. 오후 09:16
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Thermo Fisher Scientific PA5104262 FOXO1/FOXO3/FOXO4 Polyclonal Antibody 100 ul pk판매 단위 pk ·
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627,600원VAT 포함 690,360원
Thermo Fisher Scientific · Thermo Fisher Scientific FOXO1/FOXO3/FOXO4 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human FOXO1 (Accession Q12778), corresponding to amino acid residues M1–A49 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853576 |
Product Specific Information
Antibody detects endogenous levels of total pan-FOXO1/3/4.
Target Information
FOXO1, FOXO3, and FOXO4 belong to the forkhead family of transcription factors.
- FOXO1 (FKHR): A 70 kDa protein acting as a coactivator or corepressor of nuclear receptor activity through the LXXLL motif in its C-terminus. The specific gene function is not fully determined.
- FOXO3: Functions as a trigger for apoptosis by inducing expression of cell death-related genes. Translocation with the MLL gene is linked to secondary acute leukemia.
- FOXO4: Regulates the insulin signaling pathway by binding to insulin-response elements (IREs) and activating IGFBP1 transcription. It down-regulates HIF1A expression and suppresses hypoxia-induced transcriptional activation, contributing to negative regulation of the cell cycle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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