Thermo Fisher Scientific Bcr Polyclonal Antibody
Human 및 Mouse 시료에 반응하는 Rabbit Polyclonal Bcr 항체로, Western Blot, IHC, ICC/IF에 사용 가능. 합성 펩타이드(aa 336–386) 기반 면역원. 1 mg/mL 농도의 액상 형태로, -20°C 보관. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BCR (Accession P11274), corresponding to amino acid residues E336–P386 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853574 |
Product Specific Information
Antibody detects endogenous levels of total Bcr.
Target Information
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, commonly found in chronic myelogenous leukemia. The chromosome 22 breakpoint occurs within the BCR gene, resulting in a fusion protein encoded by sequences from both BCR and ABL. While the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product remains unclear. The BCR protein exhibits serine/threonine kinase activity and acts as a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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