Thermo Fisher Scientific ENPP2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Positive test controls include: HepG2, A-549, and Mouse kidney.
The target is typically localized in secreted regions.

Immunogen sequence:

DLGCTCDDKV EPKNKLDELN KRLHTKGSTE ERHLLYGRPA VLYRTRYDIL 
YHTDFESGYS EIFLMPLWTS YTVSKQAEVS SVPDHLTSCV RPDVRVSPSF 
SQNCLAYKND KQMSYGFLFP PYLSSSPEAK YDAFLVTNMV PMYPAFKRVW 
NYFQRVLVKK YASERNGVNV ISGPIFDYDY DGLHDTEDKI KQYVEGSSIP 
VPTHYYSIIT SCLDFTQPAD KCDGPLSVSS FILPHRPDNE ESCNSSEDES 
KWVEELMKMH TARVRDIEHL TSLDFFRKTS RSYPEILTLK TYLHTYESEI

Target Information

The ENPP2 gene encodes a protein with dual enzymatic functions:

• Acts as a phosphodiesterase, cleaving phosphodiester bonds at the 5’ end of oligonucleotides.
• Functions as a phospholipase, catalyzing production of lysophosphatidic acid (LPA) in extracellular fluids.

LPA mediates growth factor-like responses such as:

• Stimulation of cell proliferation
• Chemotaxis
• Tumor cell motility
• Angiogenesis

Expression of this gene is upregulated in several carcinomas. The protein is secreted and processed into its biologically active form. Multiple alternatively spliced transcript variants exist, encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.