Thermo Fisher Scientific Phospho-PLCG2 (Tyr1197) Polyclonal Antibody
PLCG2 단백질의 Tyr1197 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 적합. 고순도 정제 및 안정적 PBS/glycerol buffer로 보관. 연구용으로만 사용.
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- PA5106102
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
- Publications: References
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PLCG2 (Accession P16885), corresponding to amino acid residues around phosphorylated Tyr1197 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817501 |
Product Specific Information
Antibody detects endogenous levels of PLCG2 only when phosphorylated at Tyr1197.
Target Information
Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in receptor-mediated signal transduction by generating inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate.
There are multiple mammalian PLC isozymes, including PLCβ1–β4, PLCγ1–γ2, PLCδ1–δ2, and PLCε.
PLCδ isoforms function in calcium signaling and are implicated in various cellular processes and diseases such as Alzheimer’s disease and gastric cancer.
PLCδ2 expression may serve as a marker of gastric malignant transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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