Thermo Fisher Scientific Phospho-Met (Tyr1365) Polyclonal Antibody
Phospho-Met (Tyr1365) 특이적 폴리클로날 항체로, 인산화된 c-Met 단백질 검출에 적합합니다. Western blot 및 면역세포염색(ICC/IF)에 사용 가능하며, 사람, 마우스, 랫트에 반응합니다. 고순도 정제 및 안정한 PBS/glycerol 저장 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MET (Accession P08581), corresponding to amino acid residues around phosphorylated Tyr1365. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817496 |
Product Specific Information
This antibody detects endogenous levels of c-Met only when phosphorylated at Tyr1365.
Target Information
MET (c-Met) is a receptor-like tyrosine kinase whose dysregulation has been linked to various human malignancies. Upon ligand activation, MET interacts with PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3, leading to activation of signaling cascades including RAS-ERK, PI3K-AKT, and PLCγ-PKC pathways.
MET plays a critical role in embryonic development such as gastrulation, muscle and neuron development, angiogenesis, and kidney formation. In adults, it contributes to wound healing, organ regeneration, and tissue remodeling.
Aberrant MET signaling has been associated with cancers including gastric, renal, and breast cancers, making it an important target for cancer therapeutics and diagnostics.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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