Thermo Fisher Scientific Ataxin 3 Recombinant Rabbit Monoclonal Antibody (7B2I1)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:5,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

7B2I1

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 190-361 of human Ataxin-3 (ATXN3) (NP_004984.2). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Ataxin 3,uniProtId:P54252-2,ncbiNodeId:9606,antigenRange:190-361,antigenLength:361,antigenImageFileName:MA5-51244_Ataxin_3_P54252-2_Rabbit.svg,antigenImageFileNamePDP:MA5-51244_Ataxin_3_P54252-2_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.53 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_3093889

Product Specific Information

Immunogen sequence: KLIGEELAQL KEQRVHKTDL ERVLEANDGS GMLDEDEEDL QRALALSRQE IDMEDEEADL RRAIQLSMQG SSRNISQDMT QTSGTNLTSE ELRKRREAYF EKQQQKQQQQ QQQQQQGDLS GQSSHPCERP ATSSGALGSD LGDAMSEEDM LQAAVTMSLE TVRNDLKTEG KK

Target Information

Machado-Joseph disease is an autosomal dominant neurologic disorder, and is now known to be the same as previously described spinocerebellar ataxia-3. MJD protein (Ataxin-3) contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. This protein interacts with key regulators (CBP, p300 and PCAF) of transcription and represses transcription, and also acts as a histone-binding protein that regulates transcription. MJD is a deubiquitinating enzyme.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.