Thermo Fisher Scientific Ataxin 3 Recombinant Rabbit Monoclonal Antibody (7B2I1)
Ataxin 3 단백질을 인식하는 재조합 토끼 단클론 항체로, WB 및 ELISA에 적합. 인간 Ataxin-3의 190-361 아미노산 서열 기반 면역원 사용. HEK293 세포 발현, Affinity chromatography로 정제. -20°C 보관, 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 7B2I1 |
| Immunogen | Recombinant fusion protein corresponding to amino acids 190–361 of human Ataxin-3 (ATXN3) (NP_004984.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.53 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3093889 |
Product Specific Information
Immunogen sequence:
KLIGEELAQL KEQRVHKTDL ERVLEANDGS GMLDEDEEDL QRALALSRQE IDMEDEEADL RRAIQLSMQG SSRNISQDMT QTSGTNLTSE ELRKRREAYF EKQQQKQQQQ QQQQQQGDLS GQSSHPCERP ATSSGALGSD LGDAMSEEDM LQAAVTMSLE TVRNDLKTEG KK
Target Information
Machado-Joseph disease (MJD) is an autosomal dominant neurologic disorder, also known as spinocerebellar ataxia-3. The MJD protein (Ataxin-3) contains (CAG)n repeats in its coding region. Expansion of these repeats from the normal 13–36 to 68–79 causes the disease. There is a negative correlation between the age of onset and the number of CAG repeats.
Ataxin-3 interacts with transcription regulators (CBP, p300, PCAF), represses transcription, and acts as a histone-binding protein involved in transcription regulation. It also functions as a deubiquitinating enzyme.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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