Thermo Fisher Scientific CYP3A4 Recombinant Rabbit Monoclonal Antibody (7K5L10)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:12,000

-

Immunocytochemistry (ICC/IF)

1:100-1:800

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

7K5L10

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 400-503 of human CYP3A4 (NP_059488.2). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CYP3A4,uniProtId:P08684-1,ncbiNodeId:9606,antigenRange:400-503,antigenLength:503,antigenImageFileName:MA5-51247_CYP3A4_P08684-1_Rabbit.svg,antigenImageFileNamePDP:MA5-51247_CYP3A4_P08684-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.53 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_3092900

Product Specific Information

Immunogen sequence: ALHRDPKYWT EPEKFLPERF SKKNKDNIDP YIYTPFGSGP RNCIGMRFAL MNMKLALIRV LQNFSFKPCK ETQIPLKLSL GGLLQPEKPV VLKVESRDGT VSGA

Target Information

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.