Thermo Fisher Scientific TFEB Recombinant Rabbit Monoclonal Antibody (8W10Y6)
TFEB 단백질을 표적으로 하는 토끼 단클론 항체로, IHC(P) 및 ELISA에 사용 가능. Mouse와 Rat 시료에 반응하며, HEK293 세포에서 발현된 재조합 항체. 고순도의 친화 크로마토그래피 정제 및 안정적인 글리세롤 보존용액 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 8W10Y6 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 50–173 of human TFEB (NP_009093.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.03 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3092436 |
Product Specific Information
Immunogen sequence:
TPAINTPVHF QSPPPVPGEV LKVQSYLENP TSYHLQQSQH QKVREYLSET YGNKFAAHIS PAQGSPKPPP AASPGVRAGH VLSSSAGNSA PNSPMAMLHI GSNPERELDD VIDNIMRLDD VLGY
Target Information
The Transcription factor EB (TFEB) is a member of the basic helix-loop-helix leucine zipper superfamily of transcription factors that is translocated in a subset of renal tumors.
Recent studies have shown that lysosomal biogenesis is regulated by TFEB, which is in turn regulated by the mammalian target of rapamycin (mTOR) complex 1.
Other evidence suggests that TFEB coordinates the major steps of the autophagic pathway by driving the expression of autophagy and lysosomal genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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