Thermo Fisher Scientific CD20 Polyclonal Antibody
Thermo Fisher Scientific의 CD20 Polyclonal Antibody는 인간 CD20 단백질을 인식하는 염소 유래 폴리클로날 항체로, WB, IHC, ICC 등 다양한 응용에 적합합니다. 고순도 액상 형태로 제공되며, B세포 관련 연구 및 면역학적 분석에 활용됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.003–0.1 µg/mL | – |
| Immunohistochemistry (IHC) | – | 4 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 6–7 µg/mL | – |
| Immunocytochemistry (ICC/IF) | – | 1 publication |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Rhesus monkey |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C terminus of MS4A1, amino acids QDQESSPIENDSSP (aa 284–297). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2297747 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:2,000.
Target Information
CD20 is a non-glycosylated surface phosphoprotein with a molecular weight of 33–37 kDa depending on phosphorylation. It is expressed on mature and most malignant B cells, a subset of T lymphocytes, and follicular dendritic cells. CD20 regulates transmembrane calcium conductance, cell cycle progression, and B-cell proliferation. It associates with lipid rafts, and its localization changes upon extracellular triggering or BCR aggregation. CD20 remains on the cell surface after antibody treatment, making it a valuable target for B-cell depletion therapies. Dysfunctions in CD20 are linked to Ms4a1-related common variable immune deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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