Thermo Fisher Scientific p16INK4a Polyclonal Antibody
Human p16INK4a 단백질을 인식하는 Goat Polyclonal 항체로, Western blot 및 IHC(P) 분석에 적합. 비결합형 액상 형태이며, 0.5 mg/mL 농도. 암 연구 및 세포주기 조절 연구용으로 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C terminus amino acids HARIDAAEGPSDIPD |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_1075225 |
Product Specific Information
This antibody is tested in Peptide ELISA with an antibody detection limit dilution of 1:32,000.
Target Information
This gene produces several transcript variants differing in their first exons. At least three alternatively spliced variants encode distinct proteins, two of which act as inhibitors of CDK4 kinase. Another transcript includes an alternate first exon located 20 Kb upstream, encoding the ARF protein, which stabilizes p53 by interacting with and sequestering MDM2, an E3 ubiquitin-protein ligase responsible for p53 degradation. Despite structural and functional differences, the CDK inhibitor isoforms and ARF protein share a role in cell cycle G1 control. This gene is often mutated or deleted in various tumors and is recognized as a key tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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