Thermo Fisher Scientific c-Cbl Polyclonal Antibody
Human, Mouse, Rat에 반응하는 Goat Polyclonal c-Cbl 항체로 Western Blot과 Immunocytochemistry에 적합. C-말단 합성 펩타이드(aa 893-906)를 면역원으로 사용. 액상형, 0.5 mg/mL 농도, TBS(pH 7.3) + 0.5% BSA, -20°C 보관.
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- PA19022
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–3 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C terminus amino acids REFVSISSPAHVAT (aa 893–906) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2070466 |
Product Specific Information
- Predicted to react with bovine, canine, human, porcine, and rat based on sequence homology.
- Tested in Peptide ELISA with antibody detection limit dilution of 1:32,000.
Target Information
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation.
Cbl-c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells, whereas other Cbl proteins are ubiquitously expressed.
Cbl-c can ubiquitinate activated EGFR and target it for degradation.
Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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