Thermo Fisher Scientific Phospho-NUMB (Ser276) Polyclonal Antibody
NUMB 단백질의 Ser276 인산화 상태를 특이적으로 검출하는 Rabbit Polyclonal 항체. Western blot에 적합하며, 인간·생쥐·랫드 반응성. 1 mg/mL 농도의 액상 형태로, PBS/glycerol buffer에 보존. 신경세포 분화 및 신호전달 연구용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NUMB (Accession P49757), corresponding to amino acid residues around phosphorylated Ser276 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816649 |
Product Specific Information
This antibody detects endogenous levels of NUMB only when phosphorylated at Ser276.
Target Information
Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca²⁺ channel (VGCC) inhibitor or by Ca²⁺ chelator.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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