Thermo Fisher Scientific Phospho-TSC2 (Ser1387) Polyclonal Antibody
인간, 생쥐, 랫트에서 인산화된 TSC2(Ser1387)를 특이적으로 검출하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 사용 가능. 고순도 정제 및 안정적 PBS/glycerol 저장용액 제공. 연구용으로만 사용.
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Thermo Fisher Scientific Phospho-TSC2 (Ser1387) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TSC2 (Accession P49815), corresponding to amino acid residues around phosphorylated Ser1387 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816650 |
Product Specific Information
This antibody detects endogenous levels of Tuberin/TSC2 only when phosphorylated at Ser1387.
Target Information
TSC2 (Tuberin, Tuberous sclerosis complex, TSC Complex Subunit 2) functions as a tumor suppressor and may play roles in vesicular transport, regulation of cell growth arrest, and transcription mediated by steroid receptors.
TSC2 associates with hamartin (TSC1) in a cytosolic complex, potentially acting as a chaperone. Phosphorylation at Ser939 and Thr1462 regulates its interaction with hamartin and is stimulated by growth factors via the PI3K/Akt pathway.
Mutations in TSC2 can lead to constitutive activation of RAP1A, contributing to diseases such as lymphangioleiomyomatosis and angiomyolipoma. Alternative splicing produces three different isoforms of TSC2.
Usage
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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