Thermo Fisher Scientific Phospho-MAP2K4 (Ser257) Polyclonal Antibody
인간, 생쥐, 랫트에서 인산화 Ser257 부위의 MAP2K4를 검출하는 Rabbit polyclonal 항체. Western blot에 사용 가능하며, 1:500~1:2,000 희석 권장. 액상 형태, 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용.
- 판매단위
- pk
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Thermo Fisher Scientific Phospho-MAP2K4 (Ser257) Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MAP2K4 (Accession P45985), corresponding to amino acid residues around phosphorylated Ser257 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816648 |
Product Specific Information
Antibody detects endogenous levels of MEK4/MKK4 only when phosphorylated at Ser257.
Target Information
MAP2K4 (MEK4) serine/threonine kinase (mitogen-activated protein kinase 4) is a dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and JNK2 as well as p38.
MAP2K4 preferentially phosphorylates the tyrosine residue of JNKs and mediates various physiological and pathophysiological processes such as responses to cellular stress and inflammatory cytokines.
MAP2K4 is important for carcinogenesis; loss-of-function mutations have been found in lung and pancreatic tumors, while a pro-oncogenic role has also been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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