Thermo Fisher Scientific APOBEC3G Polyclonal Antibody
APOBEC3G 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF, ELISA 등 다양한 응용에 적합. 인간, 생쥐, 랫트 반응성. 고순도 친화 크로마토그래피 정제, 액상 형태, -20°C 보관.
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Thermo Fisher Scientific APOBEC3G Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 244–257 of human APOBEC3G (NP_068594.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.76 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805489 |
Product Specific Information
- Positive Samples: Cellular Location – Cytoplasm, Nucleus, P-body
- Immunogen Sequence: NQAPHKHGFL EGRH
Target Information
The Apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like (APOBEC) 3 family is a group of cytidine deaminases acting on monomeric nucleoside and nucleotide substrates. APOBEC3G, along with APOBEC3F, contributes to cellular defense against retroviral infection by being incorporated into HIV-1 virions and inducing hypermutation in viral DNA, destabilizing the viral genome. The HIV-1 Vif protein counteracts this defense by promoting ubiquitination and degradation of APOBEC3G. A single amino acid substitution (D128K) prevents APOBEC3G depletion while maintaining its antiviral activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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