Thermo Fisher Scientific TIM17 Polyclonal Antibody
Rabbit polyclonal antibody targeting human TIMM17A (TIM17). Validated for WB and ICC/IF applications. Recognizes mitochondrial inner membrane protein involved in preprotein translocation. Supplied as unconjugated liquid, 2.23 mg/mL, stored at -20°C.
- 카탈로그번호
- PA589308
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TIM17 Polyclonal Antibody
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 1–171 of human TIMM17A (NP_006326.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.23 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805482 |
Product Specific Information
Immunogen sequence:
MEEYAREPCP WRIVDDCGGA FTMGTIGGGI FQAIKGFRNS PVGVNHRLRG SLTAIKTRAP QLGGSFAVWG GLFSMIDCSM VQVRGKEDPW NSITSGALTG AILAARNGPV AMVGSAAMGG ILLALIEGAG ILLTRFASAQ FPNGPQFAED PSQLPSTQLP SSPFGDYRQY Q
Positive Samples:
NCI-H460, HeLa, A-549, MCF-7, HT-29, Mouse kidney, Mouse heart
Cellular Location:
Mitochondrion inner membrane, Multi-pass membrane protein
Target Information
Translocation of nuclear-encoded preproteins into the mitochondrial matrix requires coordinated action of the translocases Tom and Tim, located in the outer and inner mitochondrial membranes, respectively.
The Tom complex includes at least eight proteins: import receptors (Tom70, Tom37, Tom22, Tom20), small proteins (Tom7, Tom6, Tom5), and the structural channel component (Tom40).
The Tim channel imports nuclear-encoded mitochondrial preproteins and involves Tim17, Tim23, and Tim44 in equimolar ratios. Tim17 exists as two isoforms (Tim17a, Tim17b) differing in their C-terminal sequences and, like Tim23, is ubiquitously expressed in fetal and adult tissues.
Tim17 and Tim23 form integral membrane proteins composing the structural elements of the inner membrane channel. Tim44 is a hydrophilic protein that recruits mitochondrial Hsp70 at the site where preproteins emerge from the Tim channel.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.