Thermo Fisher Scientific DNMT3L Polyclonal Antibody
DNMT3L 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot 및 ELISA에 적합하며, Human과 Mouse 시료에서 반응. 액상 형태로 제공되며 -20°C에서 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 151–386 of human DNMT3L (NP_7870631) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.06 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805488 |
Product Specific Information
Immunogen sequence:
SGLLQRRRKW RSQLKAFYDR ESENPLEMFE TVPVWRRQPV RVLSLFEDIK KELTSLGFLE SGSDPGQLKH VVDVTDTVRK DVEEWGPFDL VYGATPPLGH TCDRPPSWYL FQFHRLLQYA RPKPGSPRPF FWMFVDNLVL NKEDLDVASR FLEMEPVTIP DVHGGSLQNA VRVWSNIPAI RSRHWALVSE EELSLLAQNK QSSKLAAKWP TKLVKNCFLP LREYFKYFST ELTSSL
Positive Samples: HeLa, Jurkat, 293T, Mouse testis, Mouse thymus, Mouse ovary, Rat testis
Cellular Location: Nucleus
Target Information
Methylation of DNA at cytosine residues in mammalian cells is a heritable, epigenetic modification critical for proper regulation of gene expression, genomic imprinting, and development. Three families of mammalian DNA methyltransferases have been identified: DNMT1, DNMT2, and DNMT3.
DNMT1 acts as a maintenance methyltransferase, while DNMT3A and DNMT3B function as de novo methyltransferases, strongly expressed in embryonic stem cells. DNMT2 shows low expression in adult tissues.
DNMT3L is a catalytically inactive regulatory factor for DNMT3A and DNMT3B, expressed at low levels in embryonic stem cells, testis, ovaries, and thymus. It forms a heterotetrameric complex with DNMT3A or DNMT3B and contains an N-terminal ADD domain and a C-terminal methyltransferase-like domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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