Thermo Fisher Scientific EAAT2 (GLT-1) (extracellular) Polyclonal Antibody, Atto 633

Applications

Immunohistochemistry (Frozen) (IHC (F))

• Tested Dilution: 1:50

Product Specifications

Product Specific Information

• Reconstitution: 50 µL double distilled water (DDW), depending on sample size
• Ships as a lyophilized powder at room temperature
• Store at -20°C upon arrival
• Reconstituted solution stable at 4°C for up to 1 week
• For long-term storage, aliquot and keep at -20°C
• Avoid multiple freeze/thaw cycles
• Centrifuge all antibody preparations before use (10,000 × g, 5 min)

Target Information

Excitatory amino acid transporter 2 (EAAT2) is a membrane-bound solute transporter responsible for clearing the excitatory neurotransmitter glutamate from the extracellular space at central nervous system synapses. Proper glutamate clearance is essential for synaptic activation and prevention of neuronal damage from excessive glutamate receptor activation. Mutations or reduced expression of EAAT2 are linked to amyotrophic lateral sclerosis (ALS). Alternatively spliced transcript variants have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.