Thermo Fisher Scientific CD104 (Integrin beta 4) Monoclonal Antibody (450-9D)
CD104 (Integrin beta 4) 단백질을 인식하는 Mouse IgG1 단일클론 항체로, WB, IHC, ICC, Flow, IP 등 다양한 분석에 사용 가능. 인간 시료 반응성, Protein G 정제, 액상 형태이며 -20°C 보관. CD104의 세포외 에피토프를 인식함.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 450-9D |
| Immunogen | Purified alpha6 beta4 integrin from A431 cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage buffer | Physiological saline |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745101 |
Additional Formats
Product Specific Information
This antibody recognizes an extracellular epitope on the CD104 molecule.
Target Information
Integrins are heterodimers composed of alpha and beta subunits, forming noncovalently associated transmembrane glycoprotein receptors. Different combinations of these subunits determine ligand-binding specificity. Integrins mediate cell-matrix and cell-cell adhesion and transmit signals regulating gene expression and cell growth.
The integrin beta 4 subunit, encoded by this gene, acts as a receptor for laminins and associates with the alpha 6 subunit. It plays a crucial role in invasive carcinoma biology. Mutations in this gene are linked to epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 관련 정보: MA5-28118_CD104_Integrin_beta_4_P16144-1_House_mouse.svg, MA5-28118_CD104_Integrin_beta_4_P16144-1_House_mouse_PDP.jpeg)
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