Thermo Fisher Scientific CD161 Monoclonal Antibody (B199.2), FITC
CD161 (KLRB1) 단백질을 인식하는 FITC 결합 단클론 항체로 인간 NK 및 T 세포 분석에 적합. Flow Cytometry에 최적화된 형광 특성(498/517 nm). Protein A로 정제되어 높은 순도와 안정성 제공. 연구용으로만 사용 가능.
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Thermo Fisher Scientific CD161 Monoclonal Antibody (B199.2), FITC
Applications
- Flow Cytometry (Flow)
Tested Dilution: Neat-1:10
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | B199.2 |
| Immunogen | Purified human NK cells cultured in IL-2 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Protein A |
| Storage buffer | PBS with 1% BSA |
| Contains | 0.09% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745104 |
Additional Formats
Product Specific Information
This antibody recognizes a similar epitope to the DX1 monoclonal antibody.
Target Information
KLRB1 (Killer cell lectin like receptor subfamily B, member 1, CD161) is a type II membrane protein with an external C terminus. It is expressed on most NK cells and a subset of CD3⁺ T cells. KLRB1 functions as an inhibitory receptor on NK cells, influencing ceramide levels and kinase activation (AKT1/PKB, RPS6KA1/RSK1). It binds carbohydrate epitopes such as Gal-α(1,3)Gal and N-acetyllactosamine, and interacts with CLEC2D/LLT1 to modulate NK cell cytotoxicity and interferon-gamma secretion. Structurally, it includes extracellular C-type lectin motifs, a transmembrane domain, and a cytoplasmic domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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