Thermo Fisher Scientific MMP-1 (Collagenase-I) Polyclonal Antibody
MMP-1(Collagenase-I)에 특이적인 Rabbit Polyclonal Antibody로, Western Blot 및 IHC(P)에서 사용 가능. Human 시료 반응성. 항원 친화 크로마토그래피로 정제되었으며, PBS 안정화 용액에 보존. 세포질 내 단백질 검출에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the N-terminus of human MMP-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Placenta, bladder, breast or ovarian carcinoma
- Cellular location: Cytoplasmic
Target Information
Matrix metalloproteinase (MMP) family proteins are involved in the breakdown of extracellular matrix during normal physiological processes such as embryonic development, reproduction, and tissue remodeling, as well as in pathological conditions like arthritis and metastasis. Most MMPs are secreted as inactive proproteins and activated upon cleavage by extracellular proteinases.
The MMP-1 gene encodes a secreted enzyme that degrades interstitial collagens types I, II, and III. It is part of an MMP gene cluster located at chromosome 11q22.3. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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