Thermo Fisher Scientific DRAM Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitute with 150 µL of distilled water.
• The antigen shares approximately 85% identity with mouse and rat sequences.

Target Information

Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. Activation of DRAM by p53 occurs concurrently with activation of proapoptotic genes such as PUMA and Bax, promoting a full cell death response. DRAM alone cannot induce apoptosis, but its inactivation in certain cancers underscores its importance and suggests a significant role of autophagy in tumor biology. At least two isoforms of DRAM are known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.