Thermo Fisher Scientific DRAM Polyclonal Antibody
DRAM 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 IHC에 적합. 합성 펩타이드 항원을 사용하여 제작되었으며, 자가포식 관련 연구에 활용 가능. 동결건조 형태로 제공되며, 장기 보관 시 -20°C에서 안정적으로 유지됨.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:2,000 |
| Immunohistochemistry (IHC) | 1:200–1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 160–210 of human DRAM conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage conditions | Store at 4°C for short term. For long-term storage, keep at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10985512 |
Product Specific Information
- Reconstitute with 150 µL of distilled water.
- The antigen shares approximately 85% identity with mouse and rat sequences.
Target Information
Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. Activation of DRAM by p53 occurs concurrently with activation of proapoptotic genes such as PUMA and Bax, promoting a full cell death response. DRAM alone cannot induce apoptosis, but its inactivation in certain cancers underscores its importance and suggests a significant role of autophagy in tumor biology. At least two isoforms of DRAM are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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