Thermo Fisher Scientific DCTN1 Polyclonal Antibody
Rabbit 폴리클로날 항체로 Human, Mouse, Rat DCTN1 단백질 검출에 사용. Western blot 및 IHC에 적합하며, 합성 펩타이드(aa 120-170)로부터 유래. 동결건조 형태로 제공되며, 4°C 또는 -20°C에서 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Miscellaneous PubMed (Misc) | – | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from aa region 120–170 of human DCTN1 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in rat and mouse.
- Specificity: DCTN1.
Target Information
The DCTN1 gene encodes the largest subunit of dynactin, a macromolecular complex of 10 subunits (22–150 kDa). Dynactin binds to both microtubules and cytoplasmic dynein and plays roles in:
- ER-to-Golgi transport
- Lysosome and endosome movement
- Spindle formation and chromosome movement
- Nuclear positioning and axonogenesis
This subunit interacts with the dynein intermediate chain and binds microtubules via a conserved CAP-Gly domain in its N-terminus.
Alternative splicing produces multiple isoforms.
Mutations in this gene are associated with distal hereditary motor neuronopathy type VIIB (HMN7B), also known as distal spinal and bulbar muscular atrophy (dSBMA).
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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