Thermo Fisher Scientific Podoplanin Recombinant Rabbit Monoclonal Antibody (ARC1488)
Recombinant rabbit monoclonal antibody against Podoplanin (ARC1488). Validated for WB and ELISA. High specificity and affinity with human and mouse reactivity. Supplied as liquid, unconjugated form, ideal for tumor and lymphatic research applications.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
- View 1 publication
ELISA
- Tested Dilution: 1 µg/mL
- View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1488 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 63–162 of human Podoplanin (Q86YL7) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849684 |
Product Specific Information
Immunogen sequence:
GLTTLVATSV NSVTGIRIED LPTSESTVHA QEQSPSATAS NVATSHSTEK VDGDTQTTVE KDGLSTVTLV GIIVGVLLAI GFIGAIIVVV MRKMSGRYSP
Target Information
Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin-type 1 glycoprotein with a molecular weight of 40–43 kDa. It is expressed in various tumors and normal cells, particularly lymphatic epithelial cells and follicular dendritic cells. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells.
As a regulator of the lymphatic endothelium, podoplanin plays a key role in maintaining the unique shape of podocytes. It serves as a ligand for CLEC-2, and its expression correlates with increased tumor invasiveness and metastatic potential. Podoplanin is directly involved in cell migration, metastasis formation, and tumor invasion. Its expression can be induced by Src activation of Cas and has been detected on Th17 cells and a subset of CD4+ cells from human PBMC.
Dysfunction of podoplanin is associated with diseases such as lymphangioma and subglottis neoplasm. It is also proposed as a marker for lung injury due to its physiological function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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