Thermo Fisher Scientific SETD7 Recombinant Rabbit Monoclonal Antibody (ARC1483)
SETD7 단백질을 인식하는 재조합 토끼 단클론 항체로 Western blot 및 ELISA에 적합. 인간, 생쥐, 랫트에 반응하며 HEK293 발현 시스템에서 생산됨. 고순도 친화 크로마토그래피 정제, 안정적 액상 형태로 -20°C 보관.
- 카탈로그번호
- MA535782
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
- Publications: View 1 publication
ELISA
- Tested Dilution: 1 µg/mL
- Publications: View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1483 |
| Immunogen | A synthetic peptide corresponding to amino acids 1–100 of human SETD7 (Q8WTS6) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.75 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849682 |
Product Specific Information
Immunogen sequence:
MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK FFFFDGSTLE GYYVDDALQG QGVYTYEDGG VLQGTYVDGE LNGPAQEYDT
Target Information
Histone methyltransferase that specifically monomethylates Lys-4 of histone H3.
H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation.
Plays a central role in transcriptional activation of genes such as collagenase or insulin.
Recruited by IPF1/PDX-1 to the insulin promoter, activating transcription.
Also methylates non-histone proteins such as p53/TP53, TAF10, and possibly TAF7.
Monomethylation of Lys-189 of TAF10 increases affinity for RNA polymerase II.
Monomethylation of Lys-372 of p53/TP53 stabilizes p53 and enhances transcriptional activation.
(Source: UniProt)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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