Thermo Fisher Scientific IREB2 Polyclonal Antibody
Thermo Fisher Scientific의 IREB2 Polyclonal Antibody는 인간 및 마우스 반응성을 가지며, Western blot, IHC, ICC/IF 등에 사용 가능합니다. 항원 친화 크로마토그래피로 정제된 비결합 항체로, 철 대사 조절 단백질 IRP2를 표적합니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | - |
| Immunocytochemistry (ICC/IF) | 1:500 | - |
| Gel Shift (GS) | Assay-dependent | - |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide made to an internal portion of the murine IRP2 protein sequence (between residues 100–200). UniProt Q811J3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.15 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2126582 |
Product Specific Information
This antibody has 94% sequence homology with human, primate, and rat.
Suggested positive control: 3T3 whole cell lysate.
Target Information
Iron regulatory protein 2 (IRP2) is a central post-transcriptional regulator of cellular and systemic iron metabolism. It is a cytosolic RNA-binding protein that binds to stem-loop structures and is regulated by iron-mediated proteolysis.
Hypoxia plays an important role in normal tissue physiology and various pathophysiological conditions such as heart and cerebrovascular diseases and tumor growth. Because iron and oxygen are closely related, IRP2 also functions during hypoxia (low oxygen).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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