Thermo Fisher Scientific TWEAK Recombinant Rat Monoclonal Antibody (MTW-1)

Thermo Fisher Scientific TWEAK Recombinant Rat Monoclonal Antibody (MTW-1)

Applications

• Flow Cytometry (Flow): Assay-dependent
• Inhibition Assays (IA): Assay-dependent

Product Specifications

Product Specific Information

• Specificity: This antibody is specific for murine TWEAK.
  It does not react with TNF-alpha, FasL, or TRAIL.

Target Information

TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF).
It is a type II transmembrane protein, with a smaller biologically active form generated by cleavage near the cell membrane.
TWEAK has multiple biological activities including:

• Stimulation of cell growth and angiogenesis
• Induction of inflammatory cytokines
• Stimulation of apoptosis

The TWEAK signal transduction pathway is mediated via TweakR/Fn14, similar to other TNFSF members that bind receptors lacking death domains.

For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.