Thermo Fisher Scientific MARCO Chimeric Recombinant Rabbit Monoclonal Antibody (PLK1)
MARCO 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC/IF, Flow cytometry, IP 등 다양한 응용에 적합합니다. 인간 시료에 반응하며, Protein A로 정제된 액상 형태로 제공됩니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PLK1 |
| Immunogen | The antibody was raised by immunising BALB/c mice with human alveolar macrophages (AMs) and subsequent creation of hybridomas. Target family: MARCO (UniProt ID: Q9UEW3-1), Antigen range: 1–520 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074671 |
Product Specific Information
Specificity: This antibody recognises the extracellular domain V between residues 420 and 431 in MARCO both in human and bovine samples.
Target Information
MARCO (Macrophage Receptor with Collagenous Structure), also known as SR-A6 or SCARA2, is a macrophage surface receptor and a member of the class A scavenger receptor family.
It plays a role in the innate antimicrobial immune system by binding both Gram-negative and Gram-positive bacteria via an extracellular scavenger receptor cysteine-rich (SRCR) domain.
The protein includes short cytoplasmic and transmembrane domains, an extracellular spacer domain, and a long collagenous domain that may form trimeric structures.
Due to its expression in tumor-infiltrating macrophages and its role in immune suppression within tumor environments, MARCO is considered a potential target for cancer immunotherapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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