Thermo Fisher Scientific FceR1 alpha Recombinant Mouse Monoclonal Antibody (IB10)
인간 FceR1 alpha 단백질을 인식하는 리콤비넌트 마우스 모노클로날 항체 IB10. IgE 결합 경쟁 특이성 보유. Flow Cytometry 및 Inhibition Assay에 적합. 단백질 A 정제, PBS 버퍼에 1 mg/mL 농도로 제공.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Inhibition Assays (IA)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | IB10 |
| Immunogen | Recombinant human protein, N-terminus |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074674 |
Product Specific Information
Specificity: This antibody binds to human Fc epsilon receptor and competes with IgE binding.
Target Information
FceR1 (Fc epsilonR1 alpha) is a subunit of the high affinity receptor of IgE. Fc epsilonR1 alpha is part of a tetrameric complex consisting of one alpha, one beta, and two additional subunits. The latter two are required for signal transduction activity.
The Fc epsilonR1 complex plays an important role in triggering allergic responses, acting as the initiator of the allergic reaction. When multiple high-affinity IgE receptors are cross-linked by allergen-bound IgE molecules, mediators such as histamine are released, leading to allergy symptoms.
This receptor couples allergen and mast cells to initiate inflammatory responses typical of disorders such as hay fever and asthma. The release of histamine and proteases induces synthesis of prostaglandins and leukotrienes, potent effectors of hypersensitivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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