Thermo Fisher Scientific alpha-Actin-1 Polyclonal Antibody

Applications and Tested Dilution

Publications: 2 publications available (Miscellaneous PubMed)

Product Specifications

Product Specific Information

If the antibody is provided in lyophilized form, reconstitute with deionized water (or equivalent) to achieve a concentration of 0.5 mg/mL.
Actin and myosin are two major cytoskeletal proteins involved in cell motility, secretion, cytoplasmic streaming, phagocytosis, and cytokinesis.
This Rabbit Anti-Alpha-Actin-1 Polyclonal Antibody was developed using a synthetic peptide conjugated to KLH.

Target Information

The gene encoding this protein belongs to the actin family, a group of highly conserved proteins essential for cell motility, structure, and integrity.

• Alpha actins: Major components of the contractile apparatus
• Beta and gamma actins: Regulate cell motility

Alpha-Actin-1 is specifically expressed in skeletal muscle.
Mutations in this gene are associated with:

• Nemaline myopathy type 3
• Congenital myopathy with excess thin myofilaments
• Congenital myopathy with cores
• Congenital myopathy with fiber-type disproportion

These conditions result in muscle fiber structural defects.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.