Thermo Fisher Scientific GAPex5 Polyclonal Antibody
GAPex5 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunoprecipitation에 적합하며, Human 반응성. 항원 친화 크로마토그래피로 정제된 액상 제품으로 안정적인 신호 검출 제공.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 700 and 750 of human GTPase activating protein and VPS9 domains 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Mouse and Bovine
Target Information
GAPVD1 acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in processes such as endocytosis, insulin receptor internalization, and LC2A4/GLUT4 trafficking.
It acts as a GEF for RAB31, regulating LC2A4/GLUT4 trafficking. In absence of insulin, it maintains RAB31 active and retains LC2A4/GLUT4 inside cells. Upon insulin stimulation, GAPVD1 translocates to the plasma membrane, releasing LC2A4/GLUT4 from storage vesicles.
It is also involved in EGFR trafficking and degradation, possibly promoting EGFR ubiquitination and proteasomal degradation.
GAPVD1 shows GEF activity for Rab5 and GAP activity for Ras.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: A302-116A_GAPVD1_Q14C86-1_Rabbit_PDP.jpeg)
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