Thermo Fisher Scientific GAPex5 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human GAPVD1 (GAPex5). Validated for Western blot and immunoprecipitation. Predicted cross-reactivity with mouse and Xenopus laevis. Supplied as unconjugated liquid form, 0.2 mg/mL concentration, stored at 4°C.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific GAPex5 Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 550 and 600 of human GTPase activating protein and VPS9 domains 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse and X. laevis
Target Information
GAPVD1 acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), participating in processes such as endocytosis, insulin receptor internalization, and LC2A4/GLUT4 trafficking.
It acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, regulating LC2A4/GLUT4 trafficking.
In the absence of insulin, GAPVD1 maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside cells. Upon insulin stimulation, it translocates to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles.
GAPVD1 is also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent proteasomal degradation. It has GEF activity for Rab5 and GAP activity for Ras.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.