Thermo Fisher Scientific ASAP1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human ASAP1 protein; validated for Western blot and immunoprecipitation; affinity-purified and supplied as liquid form; suitable for research on membrane trafficking and cancer-related pathways.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 700 and 750 of human ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, and Bovine.
Target Information
ASAP1 (Development and differentiation enhancing factor 1) is a protein containing two ANK repeats, an Arf-GAP domain, a PH domain, and an SH3 domain. It forms a homodimer and interacts with SRC and CRK, with activity stimulated by phosphatidylinositol 4,5-biphosphate (PIP2). ASAP1 exhibits GTPase-activating protein activity for ARF1 and ARF5, and lesser activity for ARF6. It may coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling and functions as a signal transduction protein involved in fibroblast differentiation into adipocytes and other cell types. It is widely expressed and recognized as a proto-oncogene implicated in invasive breast cancer and other malignant tumors, including uveal melanomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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