Thermo Fisher Scientific NMDAR2D Polyclonal Antibody
Rabbit polyclonal antibody targeting human NMDAR2D (amino acids 661–710). Suitable for IHC and IHC(P) applications. Detects endogenous 170 kDa protein with >95% purity. Supplied unconjugated in PBS buffer with sodium azide; ideal for neuroscience resea...
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: Not specified
- View 1 publication
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 661–710 of human NMDA epsilon4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2553577 |
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 170 kDa.
Purity is >95% by SDS-PAGE.
Target Information
Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development, and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA and kainate/AMPA receptors, both containing glutamate-gated, cation-specific ion channels.
Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits (GluR-1 to -7). The kainate/AMPA receptors are primarily responsible for fast excitatory neurotransmission by glutamate, whereas NMDA receptors exhibit slower kinetics and high Ca²⁺ permeability.
NMDA receptors consist of five subunits: epsilon 1–4 and one zeta subunit. The zeta subunit is expressed throughout the brainstem, while the epsilon subunits display limited distribution.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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