Thermo Fisher Scientific IL4R Polyclonal Antibody
Thermo Fisher Scientific의 IL4R Polyclonal Antibody는 인간 IL4Rα를 인식하는 토끼 폴리클로날 항체입니다. Western blot과 IHC(P)에서 검증되었으며, 항원 친화 크로마토그래피로 정제되었습니다. 1 mg/mL 농도의 액상 형태로 제공되며, 4°C 또는 -20°C에서 보관 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 220–265 of human IL-4R alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553569 |
Product Specific Information
This antibody detects endogenous IL4Rα protein at a molecular weight of approximately 88 kDa.
Purity is greater than 95% as determined by SDS-PAGE.
Target Information
IL4 Receptor alpha (IL4RA) is the alpha chain of the interleukin-4 receptor that binds to both interleukin-4 and interleukin-13 to regulate IgE production, chemokine, and mucus production at sites of allergic inflammation.
The IL4 response promotes Th2 differentiation. The secreted extracellular domain of IL4R alpha (sIL4Rα) can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells, but lacks signaling ability.
Allelic variations in the IL4RA gene have been associated with atopy, which can manifest as allergic rhinitis, sinusitis, asthma, or eczema.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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