Thermo Fisher Scientific GUCY1B2 Polyclonal Antibody
GUCY1B2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 사람, 생쥐, 랫트에 반응하며 IHC(P)에서 1:50–1:200 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제된 고순도 항체로 연구용에 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 71–120 of human GCS-beta-2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553570 |
Product Specific Information
This antibody detects endogenous protein at a molecular weight of approximately 70 kDa.
Purity is >95% by SDS-PAGE.
Target Information
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase:
- Soluble form (GCS or sGC): Acts as a receptor for nitric oxide (NO).
- Membrane-bound form (GC): Functions as a peptide hormone receptor.
GCS synthesizes cGMP and serves as the major receptor for NO, playing a crucial role in smooth muscle contractility, platelet reactivity, and neurotransmission.
It is a heme-containing heterodimer composed of one 72 kDa alpha subunit and one 65 kDa beta subunit. The heme moiety mediates NO activation and also binds carbon monoxide, which weakly stimulates the enzyme.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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