Thermo Fisher Scientific PSMA Monoclonal Antibody (GCP-05)
PSMA 단백질을 표적하는 마우스 단클론 항체로, 인간 시료에 반응합니다. ICC/IF, Flow Cytometry, IP 등 다양한 실험에 사용 가능하며, Protein A로 정제된 액상 형태입니다. 암 및 신경계 연구용으로 적합하며 4°C에서 보관합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunocytochemistry (ICC/IF) | Assay-dependent | View 1 publication |
| Flow Cytometry (Flow) | 1–4 µg/mL | – |
| Immunoprecipitation (IP) | Assay-dependent | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GCP-05 |
| Immunogen | Amino acids 44–750 of human GCPII (PSMA, UniProt ID: Q04609-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156193 |
Additional Formats
Product Specific Information
This antibody recognizes the extracellular domain (preferentially in native form) of glutamate carboxypeptidase II (NAALADase, FOLH1, PSMA), an approximately 95–110 kDa transmembrane glycoprotein expressed mainly in tumor neovasculatures, nervous system, and jejunum. It is an important prostate tumor marker.
Target Information
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on substrates including folate and N-acetyl-L-aspartyl-L-glutamate. It is expressed in tissues such as prostate, central and peripheral nervous system, and kidney.
Mutations may cause impaired intestinal folate absorption and hyperhomocysteinemia. In the brain, expression is linked to conditions involving glutamate excitotoxicity. In prostate tissue, the protein is up-regulated in cancerous cells and serves as a diagnostic and prognostic marker for prostate cancer.
Alternative splicing produces multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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