Thermo Fisher Scientific FOXP3 Monoclonal Antibody (3G3), PE

Applications

• Flow Cytometry (Flow)

Tested Dilution: 1–5 µg/mL
Publications: - References

Product Specifications

Additional Formats

• Unconjugated
• Alexa Fluor 488
• Alexa Fluor 647
• APC
• Request custom conjugation

Product Specific Information

This antibody recognizes the N-terminal region of FoxP3, a 47–55 kDa transcription factor (intracellular antigen), which is the master regulator in the development and function of regulatory T cells.

Target Information

FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis.
FOXP3 is 381 amino acids long, stably and constitutively expressed at high levels in CD25⁺ CD4⁺ regulatory T cells, low levels in CD4⁺/CD25⁻ cells, and absent in CD4⁻/CD8⁺ T cells.
Defects in FOXP3 cause scurfy phenotype in mice and IPEX syndrome in humans. FOXP3 expression is regulated by p53 in response to DNA damage in human breast and colon cancer cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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