Thermo Fisher Scientific FOXP3 Monoclonal Antibody (3G3), PE
FOXP3 단백질을 인식하는 단클론 항체로, 인체 및 마우스 시료에서 조절 T세포 연구에 적합합니다. PE 형광 표지로 유세포분석에 최적화되어 있으며, 고순도 크로마토그래피로 정제되었습니다. 4°C 암소 보관, 동결 금지.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: 1–5 µg/mL
Publications: - References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3G3 |
| Immunogen | Full-length His-tagged recombinant murine FoxP3 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Size-exclusion chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153070 |
Additional Formats
Product Specific Information
This antibody recognizes the N-terminal region of FoxP3, a 47–55 kDa transcription factor (intracellular antigen), which is the master regulator in the development and function of regulatory T cells.
Target Information
FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis.
FOXP3 is 381 amino acids long, stably and constitutively expressed at high levels in CD25⁺ CD4⁺ regulatory T cells, low levels in CD4⁺/CD25⁻ cells, and absent in CD4⁻/CD8⁺ T cells.
Defects in FOXP3 cause scurfy phenotype in mice and IPEX syndrome in humans. FOXP3 expression is regulated by p53 in response to DNA damage in human breast and colon cancer cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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