Thermo Fisher Scientific CRYAB Monoclonal Antibody (OTI5D8), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found in vertebrate skeletal muscle tissue.
In the lens, their structural role is to maintain the proper refractive index. The mammalian lens contains three major classes of crystallins: alpha, beta, and gamma.

Alpha-crystallin is the largest and composed of two primary gene products—alpha-A and alpha-B.
Alpha-Crystallin makes up approximately 40% of total lens protein and functions as a molecular chaperone, preventing aggregation that may lead to cataract formation.
Phosphorylation of alpha-crystallin occurs in response to cellular stress and may play a role in structural control and protein maintenance.
Alpha-B crystallin has been linked to Alexander’s disease, where it accumulates in brain cells of affected individuals.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.