Thermo Fisher Scientific CD18 (LFA-1 beta) Recombinant Rabbit Monoclonal Antibody (JM71-31)
Recombinant rabbit monoclonal antibody targeting human CD18 (LFA-1 beta). Validated for Western blot with high specificity and sensitivity. Offers lot-to-lot consistency and animal origin-free formulation. Ideal for research on leukocyte adhesion and i...
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Applications
- Western Blot (WB): Tested dilution 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM71-31 |
| Immunogen | Synthetic peptide within Human CD18 (aa 103–146) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809921 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Specific antibody DNA sequences are cloned from immunoreactive rabbits, and individual clones are screened for optimal production.
Advantages include:
- Superior specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to the rabbit immune repertoire
Target Information
CD18 (integrin beta 2 subunit) is a 90 kDa type I transmembrane protein expressed on all leukocytes. It forms heterodimers with CD11a–d molecules to create leukocyte (β2) integrins such as:
- αLβ2 (CD11a/CD18, LFA-1)
- αMβ2 (CD11b/CD18, Mac-1, CR3)
- αXβ2 (CD11c/CD18)
- αDβ2 (CD11d/CD18)
These integrins mediate cell adhesion and signaling, essential for leukocyte migration and intercellular contact.
Defects in CD18 cause leukocyte adhesion deficiency type I (LAD1), and reduced expression is linked to psoriasiform skin disease. CD18 also mediates cytolysis induced by Mannheimia haemolytica leukotoxin.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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