Thermo Fisher Scientific MRE11 Recombinant Rabbit Monoclonal Antibody (JM11-18)
MRE11 단백질을 표적하는 재조합 토끼 단일클론 항체로, Western blot과 IHC에 적합. 높은 특이성과 민감도, 로트 간 일관성 제공. 동물 유래 성분이 없는 포뮬레이션으로 다양한 종에 반응. 연구용으로 DNA 손상 복구 관련 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
- Publications: References
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM11-18 |
| Immunogen | Synthetic peptide within Human MRE11 (aa 465–498) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809925 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to large rabbit immune repertoire
Target Information
MRE11 (double-strand break repair protein MRE11) is a component of the MRN complex, which plays a central role in:
- Double-strand break repair
- DNA recombination
- Maintenance of telomere integrity
- Meiosis
The complex possesses single-stranded endonuclease and double-strand-specific 3′–5′ exonuclease activity provided by MRE11. RAD50 binds DNA ends and maintains proximity.
Mutations in the MRE11 gene may lead to ataxia-telangiectasia-like disorder 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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