Thermo Fisher Scientific MRE11 Recombinant Rabbit Monoclonal Antibody (JM11-18)

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000
• Publications: References

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200
• Publications: References

Product Specifications

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates.
Advantages include:

• Enhanced specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to large rabbit immune repertoire

Target Information

MRE11 (double-strand break repair protein MRE11) is a component of the MRN complex, which plays a central role in:

• Double-strand break repair
• DNA recombination
• Maintenance of telomere integrity
• Meiosis

The complex possesses single-stranded endonuclease and double-strand-specific 3′–5′ exonuclease activity provided by MRE11. RAD50 binds DNA ends and maintains proximity.
Mutations in the MRE11 gene may lead to ataxia-telangiectasia-like disorder 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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