Thermo Fisher Scientific TDP-43 Polyclonal Antibody
TDP-43 단백질 검출용 Rabbit Polyclonal Antibody로 인간, 생쥐, 랫트 반응성. Western blot 및 Immunocytochemistry에 적합하며, 항원 친화 크로마토그래피로 정제됨. 연구용으로 HIV-1 TAR DNA 결합 및 신경퇴행성 질환 관련 연구에 활용 가능.
- 카탈로그번호
- PA520409
- 판매단위
- pk
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Thermo Fisher Scientific TDP-43 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–1.0 µg/mL |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide from near the center of human TDP43 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Refrigerate at 2–8°C for up to 3 months; for long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153968 |
Product Specific Information
- Suggested positive control: L1210 cell lysate
- PA5-20409 can be used with blocking peptide PEP-0526.
Target Information
TDP43 was identified as a cellular protein binding to HIV-1 TAR DNA sequence motifs, acting as a transcriptional repressor to the HIV-1 LTR. It also regulates splicing of exon 9 of CFTR, likely through association with UG repeats at the 3′ splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 (pathologic TDP43) is a major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is distinct from TRBP1, an RNA-binding protein that binds HIV-1 TAR RNA sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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