Thermo Fisher Scientific TDP-43 Polyclonal Antibody

Thermo Fisher Scientific TDP-43 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Suggested positive control: L1210 cell lysate
• PA5-20409 can be used with blocking peptide PEP-0526.

Target Information

TDP43 was identified as a cellular protein binding to HIV-1 TAR DNA sequence motifs, acting as a transcriptional repressor to the HIV-1 LTR. It also regulates splicing of exon 9 of CFTR, likely through association with UG repeats at the 3′ splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 (pathologic TDP43) is a major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is distinct from TRBP1, an RNA-binding protein that binds HIV-1 TAR RNA sequences.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.