Thermo Fisher Scientific STEAP3 Polyclonal Antibody
STEAP3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 사용 가능. 인체, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태. 철 및 구리 환원 관련 연구에 적합.
- 카탈로그번호
- PA520406
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | 2.5 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 20 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid peptide from near the amino terminus of human STEAP3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154091 |
Product Specific Information
- A suggested positive control is rat liver tissue lysate.
- PA5-20406 can be used with blocking peptide PEP-0523.
Target Information
The six-transmembrane epithelial antigen of prostate 3 (STEAP3) is a member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. Similar to other STEAP family members (STEAP2 and STEAP4), STEAP3 promotes both iron and copper reduction. It is highly expressed in hematopoietic tissues and colocalizes with the transferrin endosome. Overexpression of STEAP3 stimulates iron reduction; mice lacking STEAP3 are deficient in erythroid ferrireductase activity, indicating that STEAP3 functions as an endosomal ferrireductase required for transferrin-dependent iron uptake in erythroid cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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