Thermo Fisher Scientific ABRA1 Polyclonal Antibody
ABRA1(CCDC98) 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC에 적합합니다. Human 및 Mouse 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 냉장 보관(2–8°C) 권장, 장기 보관 시 -20°C. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid peptide from near the amino terminus of human CCDC98 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage, store at -20°C. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156849 |
Product Specific Information
- A suggested positive control is human breast tissue lysate.
- PA5-20412 can be used with blocking peptide PEP-0529.
Target Information
CCDC98, also known as Abraxas 1, was identified through protein binding studies using BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing BRCA1 foci formation in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair.
Cells depleted of either CCDC98 or RAP80 exhibit increased sensitivity to ionizing radiation, though less than BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of BRCA1’s DNA damage response role. At least two isoforms of CCDC98 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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