Thermo Fisher Scientific APE1 Polyclonal Antibody
APE1 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체로, WB, IHC, ICC, Flow, IP 등 다양한 응용에 적합. Human, Mouse 등 다종 반응성. 고순도 항원 친화 크로마토그래피 정제. DNA 손상 복구 및 산화 신호 조절 연구용.
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Thermo Fisher Scientific APE1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1 µg/mL |
| Immunoprecipitation (IP) | 7 µg/mL |
| ChIP assay (ChIP) | 1:10–1:500 |
| Neutralization (Neu) | 50–200 molar excess |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rabbit, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Affinity purified human Apurinic/Apyrimidinic Endonuclease (APE/ref-1) fusion protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2242859 |
Product Specific Information
- In IHC applications, this antibody can be competitively inhibited from recognizing the APE1 antigen in tissues using APE1 protein.
- This antibody can be used on frozen sections, fixed-paraffin sections, and cytospin preparations.
- Suggested positive control: HeLa whole cell extract, antigen standard for APEX1 (transient overexpression lysate).
Target Information
Mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is a multifunctional, bipartite enzyme involved in numerous cellular functions. APE repairs abasic sites in DNA and regulates the redox state of proteins associated with oxidative signaling, transcription factor regulation (Fos, Jun, NF-kB, Myb, HIF-1α, CREB, Pax), cell cycle control (p53), and apoptosis.
Abasic site formation occurs via spontaneous loss, oxidative DNA damage, chemotherapy-induced hydrolysis, ionizing radiation, UV irradiation, oxidizing agents, and DNA glycosylase activity.
APE expression varies across developmental stages and tissues, with diverse subcellular localization supporting its interaction with other cellular proteins beyond nuclear DNA repair.
Phosphorylation-mediated regulation by casein kinase II has been reported. Increased APE levels are observed upon reoxygenation of hypoxic cells and in malignant tissues compared to normal ones, while decreased expression correlates with apoptosis induction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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