Thermo Fisher Scientific Phospho-PAK6 (Ser165) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:50
• Publications: -

Product Specifications

Product Specific Information

This antibody was cross-adsorbed to unphosphorylated PAK6 (Ser-165) peptide then affinity purified using phospho-PAK6 (Ser-165) peptide.
The antibody detects a 75 kDa* band on SDS-PAGE immunoblots of human PAK6 recombinant protein phosphorylated with ERK2.
This reactivity is specifically blocked by pre-incubation with phospho-PAK6 (Ser-165) peptide and also by treatment with lambda phosphatase.

Target Information

PAK6 is a serine/threonine kinase expressed in the testis and prostate. It associates with both the estrogen and androgen receptors.
The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac.
They are divided into two groups:

• Group 1 (PAK1, 2, 3): Activated by Cdc42/Rac binding and involved in gene transcription, apoptosis, and cell morphology/motility.
• Group 2 (PAK4, 5, 6): Not activated by Cdc42/Rac binding. PAK6 may be activated by MAP kinase kinase 6 and p38 MAP kinase, suggesting a role in cellular stress response.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.