Thermo Fisher Scientific Phospho-PAK6 (Ser165) Polyclonal Antibody
Phospho-PAK6 (Ser165) 특이적 폴리클로날 항체로, 인간 PAK6 인산화 단백질 검출에 적합. Western blot에 검증됨. 항원 친화 정제 방식으로 고순도 확보. 연구용으로 세포 신호전달 및 스트레스 반응 연구에 활용 가능.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:50
- Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | PAK6 (Ser-165) synthetic peptide (coupled to carrier protein) corresponding to amino acids around serine 165 in human PAK6. The sequence used has two amino acid differences compared to rat and mouse PAK6. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2942963 |
Product Specific Information
This antibody was cross-adsorbed to unphosphorylated PAK6 (Ser-165) peptide then affinity purified using phospho-PAK6 (Ser-165) peptide.
The antibody detects a 75 kDa* band on SDS-PAGE immunoblots of human PAK6 recombinant protein phosphorylated with ERK2.
This reactivity is specifically blocked by pre-incubation with phospho-PAK6 (Ser-165) peptide and also by treatment with lambda phosphatase.
Target Information
PAK6 is a serine/threonine kinase expressed in the testis and prostate. It associates with both the estrogen and androgen receptors.
The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac.
They are divided into two groups:
- Group 1 (PAK1, 2, 3): Activated by Cdc42/Rac binding and involved in gene transcription, apoptosis, and cell morphology/motility.
- Group 2 (PAK4, 5, 6): Not activated by Cdc42/Rac binding. PAK6 may be activated by MAP kinase kinase 6 and p38 MAP kinase, suggesting a role in cellular stress response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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