Thermo Fisher Scientific Phospho-p130Cas (Tyr751) Polyclonal Antibody

Thermo Fisher Scientific Phospho-p130Cas (Tyr751) Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 1:1,000

Product Specifications

Product Specific Information

This antibody was cross-adsorbed to phospho-tyrosine coupled to agarose and to phospho-p130 Cas (Tyr-762) peptide before affinity purification using phospho-p130 Cas (Tyr-751) peptide (without carrier).
The antibody detects a 130 kDa* protein corresponding to the molecular mass of phosphorylated p130 Cas on SDS-PAGE immunoblots of pervanadate-treated human endothelial and A431 cells, but is not observed in control cells.

Target Information

The p130Cas (Cas for Crk-associated substrate) is a common cellular target of phosphorylation signaling via v-Crk and v-Src oncoproteins.
p130Cas has a unique structure containing an SH3 domain followed by multiple YXXP motifs and a proline-rich region.
It is implicated in diverse biological processes including:

• Cell adhesion
• Cell migration
• Growth factor stimulation
• Cytokine receptor engagement
• Bacterial infection

Physiological functions of p130Cas include cardiovascular development, actin filament assembly, and Src-induced cell transformation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.