Thermo Fisher Scientific Tau (Cleaved Asp421, Asp422) Monoclonal Antibody (TauC3)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody recognizes tau when truncated at Asp421. Several caspases, including caspase-3, caspase-7, and caspase-8, cleave tau at this site, yielding the truncated form of the protein.
This antibody does not react with full-length tau, or with tau truncated at Glu391 or Ala429.
It provides a useful tool for studying neuronal cell apoptosis.

Recommended Positive Control: Tau and caspase-3 cleaved tau.

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules.
The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker between both structures.
Axonal polarity is determined by Tau/MAPT localization near the centrosome.
Short isoforms allow cytoskeletal plasticity, while longer isoforms contribute to stabilization.
In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), which form neurofibrillary lesions in Alzheimer’s disease brain.
Hyper-phosphorylation impairs Tau’s microtubule binding, leading to destabilization and neuronal degeneration.
Tau is phosphorylated by several kinases, including GSK-3β, PKA, cdk5, and casein kinase II.
Hyper-phosphorylated Tau is also found in other neurodegenerative disorders such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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